A high-profile murder in the metropolis of Ravnica calls for the best Magic: the Gathering detectives! Work with Kaya, Kellan and Alquist Proft (of the Ravnican Agency of Magicological Investigations) to prevent more victims and track down the perpetrator. Search for clues at the crime scene, examine the murder weapon and interrogate suspects. Is there a serial killer sneaking through Ravnica or is there a dark plot afoot...?

A prerelease pack contains:

- 6 play boosters
- 1 prerelease promo of Murders at Karlov Manor (this can be any rare or mythic from the set)
- 1 of three different prerelease pack exclusive mythic rares.
- 1 spindown die from Murders at Karlov Manor